TESAMORELIN

Name: TESAMORELIN
Brand: TESAMORELIN
SKU: PEPT-TESA-008
Availability: InStock

Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH) consisting of 44 amino acids, designed exclusively for laboratory research. This peptide analogue corresponds to the biologically active fragment of endogenous human GHRH with enhanced stability and potency.

Used primarily in preclinical metabolic and endocrinology research, Tesamorelin functions as a selective GHRH receptor agonist, stimulating pulsatile growth hormone (GH) secretion from the anterior pituitary. Unlike growth hormone itself, Tesamorelin preserves the physiological negative feedback loop, making it a valuable research tool for studying the GH/IGF-1 axis without complete HPA suppression. Each lyophilised vial is synthesised to ≥98% purity, verified by independent HPLC and mass spectrometry.

Key Features

High Purity: ≥98% confirmed by third-party HPLC analysis
GHRH Analogue: Synthetic 44-amino-acid peptide with enhanced stability
Preserves Feedback Loops: Stimulates endogenous GH secretion without abolishing negative feedback
Stable Lyophilised Format: Easy reconstitution for cell culture or preclinical research
Research Use Only: Not for human consumption, clinical use, or therapeutic application

Specifications

Specification	Detail
Molecular Formula	C₂₂₁H₃₆₆N₇₂O₆₆S
Molecular Weight	5,135.84 g/mol
Sequence	H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂
Purity	≥98% (HPLC)
Appearance	White lyophilised powder
Storage (Lyophilised)	-20°C, protected from light and moisture
Storage (Reconstituted)	2-8°C for up to 7 days; aliquot for longer storage

Research Applications

Tesamorelin is widely used in preclinical studies investigating:

Metabolic Research: Visceral adipose tissue reduction, lipid metabolism, and body composition
Neuroendocrinology: GHRH receptor signalling, hypothalamic-pituitary axis regulation
Ageing & GH Decline: Age-related GH deficiency and metabolic dysfunction models
Cognitive Function: GH/IGF-1 axis effects on memory, learning, and neuroprotection
Bone Metabolism: Osteoblast activity and bone mineral density studies

Typical Research Parameters

Parameter	Recommendation
Reconstitution	Sterile water or bacteriostatic water (0.9% benzyl alcohol)
In Vitro Concentration	10 nM – 1 µM (pituitary cell cultures)
Preclinical Dosage (Rodent)	0.5–2 mg/kg, subcutaneous (once daily)
Peak GH Stimulation	60–90 minutes post-administration in research models

Note: These are references for laboratory protocol design only, not medical dosing instructions.

Mechanism of Action

Tesamorelin exerts its research-documented effects through:

GHRH Receptor Activation: Binds to GHRH receptors on somatotroph cells in the anterior pituitary
Pulsatile GH Secretion: Stimulates endogenous GH release in a physiological pattern
IGF-1 Elevation: Increases hepatic IGF-1 production via GH stimulation
Preserved Feedback: Negative feedback loop (GH/IGF-1 → hypothalamic somatostatin) remains intact
Visceral Fat Reduction: Modulates lipid metabolism independently of total body weight changes

Comparison: Tesamorelin vs. Other GHRH Analogues

Feature	Tesamorelin	Sermorelin	CJC-1295
Amino Acids	44	29	30
Half-Life (Research Models)	~30–60 minutes	~10–15 minutes	~6–8 days (with DAC)
GHRH Receptor Affinity	High	Moderate	High
Dosing Frequency (Preclinical)	Daily	Daily	Intermittent
Primary Research Focus	Metabolic, visceral fat	GH deficiency	Long-acting GH stimulation

Quality Assurance

This Tesamorelin product undergoes rigorous quality control, including:

HPLC Purity Verification: ≥98% with full chromatographic trace
Mass Spectrometry Confirmation: Molecular weight validated (ESI-MS)
Endotoxin Testing: <1 EU/mg for cell culture compatibility
Batch Tracking: Certificate of Analysis available for each lot

Shipping & Storage

Shipping: Ambient with cold pack (2–8°C recommended during transit)
Upon Arrival: Store lyophilised material at -20°C immediately
Avoid Freeze-Thaw: Aliquot reconstituted peptide to prevent degradation
Shelf Life: 12 months from the manufacture date when stored as directed at -20°C