SELANK

Name: SELANK
Brand: SELANK
SKU: PEPT-SELK-009
Availability: InStock

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) structurally related to the heavy chain of human immunoglobulin G. This peptide is designed exclusively for laboratory research into anxiety, cognition, neuroinflammation, and immune system modulation.

Unlike traditional benzodiazepines, Selank modulates neurotrophic factors and cytokine balance without direct GABA-A receptor agonism, offering a distinct mechanism of action for preclinical neuroscience research. Each lyophilized vial is synthesized to ≥98% purity, verified by independent HPLC and mass spectrometry. Researchers utilize Selank to study the interface between the nervous and immune systems, particularly in models of stress, anxiety, and cognitive impairment.

Key Features

High Purity: ≥98% confirmed by third-party HPLC analysis
Immunoglobulin-Derived Sequence: Unique heptapeptide with immunomodulatory properties
Non-Sedating Mechanism: No direct GABA-A receptor agonism observed in research models
Stable Lyophilized Format: Easy reconstitution for cell culture or preclinical research
Research Use Only: Not for human consumption, clinical use, or therapeutic application

Specification	Detail
Molecular Formula	C₃₃H₅₇N₁₁O₉
Molecular Weight	751.87 g/mol
Sequence	Thr-Lys-Pro-Arg-Pro-Gly-Pro
Purity	≥98% (HPLC)
Appearance	White lyophilized powder
Storage (Lyophilized)	-20°C, protected from light and moisture
Storage (Reconstituted)	2-8°C for up to 7 days; aliquot for longer storage

Selank is widely used in preclinical studies investigating:

Anxiety & Stress Research: Elevated plus maze, open field, and social interaction models
Cognitive Function: Learning, memory consolidation, and attention in rodent models
Neuroinflammation: Cytokine modulation (IL-6, TNF-α, IFN-γ) and microglial activation
Neurotrophic Factors: BDNF and NGF expression in hippocampal and cortical tissues
Immune-Neural Interface: Studying stress-induced immunosuppression and recovery

Parameter	Recommendation
Reconstitution	Sterile water or PBS (pH 7.0–7.4)
In Vitro Concentration	1–100 µM (neuronal or microglial cultures)
Preclinical Dosage (Rodent)	0.1–1 mg/kg, intraperitoneal, intranasal, or subcutaneous
Onset of Anxiolytic Effects (In Vivo)	30–60 minutes post-administration

Note: These are references for laboratory protocol design only, not medical dosing instructions.

Selank exerts its research-documented effects through:

Neurotrophin Upregulation: Increases BDNF and NGF mRNA expression in the hippocampus and amygdala
Cytokine Modulation: Reduces pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) while preserving anti-inflammatory IL-10
Enkephalin Degradation Inhibition: Weak inhibitor of carboxypeptidase A (enkephalinase), prolonging endogenous enkephalin activity
GABA-A Receptor Modulation: Indirect allosteric modulation without direct agonism (distinct from benzodiazepines)
Serotonin System Regulation: Normalizes 5-HT levels in stress-exposed research models

Feature	Selank	Semax	N-PEP-12
Amino Acids	7	7	12
Origin	Immunoglobulin G heavy chain	ACTH (4-10) fragment	Brain-derived
Primary Mechanism	Neurotrophin upregulation, cytokine modulation	BDNF, NGF, antioxidant	Neurotrophic
Primary Research Focus	Anxiety, stress, and immune modulation	Cognition, neuroprotection, stroke recovery	Memory, learning
Route of Administration (Preclinical)	IP, IN, SC	IP, IN, SC	Oral, IP

Shipping: Ambient with cold pack (2–8°C recommended during transit)
Upon Arrival: Store lyophilized material at -20°C immediately
Avoid Freeze-Thaw: Aliquot reconstituted peptide to prevent degradation
Shelf Life: 12 months from the manufacture date when stored as directed at -20°C